CEA-LETI (France)

Assay Development
CEA-LETI, the Laboratory for Electronics & Information Technology is operated by Direction de la Recherche Technologique at CEA, the French Atomic Energy and Commission.

It mainly aims at helping companies to increase their competitiveness through technological innovation and transfer of its technical know-how to industry. Major player in the MINATEC Micro-Nano technologies innovation center, CEA-LETI benefits from 8000 m2 state-of-the-+art clean rooms, with equipment worth some 160 million euros. It is currently employing some 1600 people among whom 1100 CEA employees and co-workers of various status including 100 people from industrial partners, working in the CEA-LETI premises within the framework of bilateral collaborations. Overall, research contracts with industry are worth 75% of CEA-LETI annual income. The laboratory is structured into six departments, with a specific department operating 24-7 the technological facilities of the silicon technology platform, and five program-oriented programs covering the field of microelectronics, microsystems, optronics, sytem design and telco, and technologies for biology and health.

The department for micro technologies in Biology and Health (DTBS) of CEA/ LETI is in charge of the implementation of micro/nanotechnologies in biology and health (160 people). The department knowledge lies in micromachining, microfluidics, surface chemistry, integrated optical detection, electrochemistry, electronics and information processing but more so in their integration in a final system, comprising instrumentation, microdevices and a biological protocol. DTBS has several industrial collaborations, in particular a joint research team with BioMerieux in the field of in vitro diagnostics. Leti has already accumulated significant microfluidic knowhow through several micro-biochip industrial projects. Facilities includes a 150m² clean room for biological microsystem development, a clean room specifically dedicated to Biochip packaging, a biological and chemical laboratory as well as specific equipment in biosensor design, manufacturing and characterization.

The different activities in this field cover:

  • grafting DNA and other biological molecules on silicone and glass substrates,
  • microfluidics, lab-on-chip, implementation of biological protocols on micro-machined ICs,
  • fluorescent detection, DNA chip readers.
  • Implantable Microsystems
  • High sensitivity detection based on nano structures (such as nanowires)

It is useful to mention that CEA/LETI’s portfolio in applications of microtechnologies for biology is larger than 140 patents.

See also: www-leti.cea.fr